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[Heart rate-ventricular extrasystole relations and their dependence on circadian rhythms]
Insights
This study found a significant linear correlation between heart rate and ventricular extrasystoles in patients with and without heart disease. Circadian rhythms of extrasystoles were observed, with variations linked to their frequency.
Area of Science:
- Cardiology
- Chronobiology
- Biomedical Engineering
Context:
- Investigating the relationship between heart rate (HR) and ventricular extrasystoles (VE) in patients with and without ischemic post-infarction cardiopathy.
- Utilizing electrocardiographic ambulatory monitoring for detailed analysis of cardiac rhythms.
Purpose:
- To analyze the linear correlation between circadian rhythms (CR) of HR and VE.
- To assess the variability of VE and its correlation with the number of recorded extrasystoles.
- To determine the significance of linear correlation between HR and VE across different patient groups and time scales.
Summary:
- A significant linear correlation between HR and VE was observed in 72% of patients with ischemic cardiopathy (group A) and 60% in those without (group B).
- Correlation significance increased with shorter analysis periods (three-minute intervals) and was more pronounced in group A when extrasystole counts exceeded 200.
- Circadian rhythm analysis revealed significant CR in 50% of group A and 60% of group B, with diurnal achrophases predominantly in group B.
Impact:
- Provides insights into the complex interplay between heart rate variability and extrasystole patterns in cardiac patients.
- Highlights the potential of analyzing circadian rhythms for understanding cardiac electrophysiology.
- Suggests that short-term analysis periods may be more effective for detecting HR-VE correlations.
Abstract:
The linear correlation of the circadian rhythms (CR) of heart rate (HR) with those of ventricular extrasystole (VE) is analyzed by electrocardiographic ambulatory monitoring in 32 patients: 22 with ischemic post-infarction cardiopathy (group A) and ten free of structural cardiopathy (group B). Variability expressed as the coefficient of ventricular extrasystole variation (100 x standard deviation/mean) presented an inverse correlation with the number of recording extrasystoles. Linear correlation between HR and VE was statistically significant in 72% of recordings in group A, and in 60% in group B. The percentage of cases with significant linear correlation was greater on analyzing the three-minute periods than with the longer periods. When the cases analyzed presented over 200 extrasystoles, the percentage with significant linear correlation between HR and extrasystole was greater in group A than in group B. The circadian rhythm of the ventricular extrasystoles using interpolation of a cosinor function was significant in 50% of group A cases, and in 60% of group B. The achrophases were diurnal in group B, but only in 45% of cases in group A, two correspondence models being found between the CR achrophases and the inverse linear correlation between HR and VE.