Related Experiment Video
Updated: Apr 29, 2026
07:09
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
51.2K
Gabapentin in acute postoperative pain management
Connie Y Chang1, Chaitanya K Challa1, Janki Shah1
1Department of Anesthesia, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB E-538, Newark, NJ 07101-1709, USA.
Biomed Research International
|May 16, 2014
Summary
Gabapentin is an effective and safe medication for managing postoperative pain. This review covers its properties, uses in pain management, and safety profile.
Area of Science:
- Pharmacology
- Anesthesiology
- Pain Management
Background:
- Gabapentin, an amino acid structurally similar to GABA, is a novel analgesic.
- It exhibits antihyperalgesic properties and a unique mechanism of action.
- Gabapentin and pregabalin are effective for neuropathic and certain postoperative pain types.
Purpose of the Study:
- To review the chemical and structural characteristics of gabapentin.
- To examine its pharmacokinetics and pharmacodynamics.
- To assess its application in acute pain management, adverse effects, and overall drug safety.
Main Methods:
- Literature review of gabapentin's properties and clinical applications.
- Analysis of pharmacokinetic and pharmacodynamic data.
- Evaluation of safety and adverse effect profiles from existing studies.
Main Results:
- Gabapentin possesses distinct chemical and structural features.
- Its pharmacokinetic and pharmacodynamic profiles support its use in pain management.
- Clinical data indicate efficacy in treating postoperative pain, with a favorable safety profile.
Conclusions:
- Gabapentin is a safe and effective option for postoperative pain management.
- The drug demonstrates antihyperalgesic properties.
- Further understanding of its mechanism and application continues to evolve.
Related Concept Videos
01:23Peripheral Artery Disease V: Postoperative Nursing Management
630
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
630
01:25Analgesia and Pain Management
3.3K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
3.3K
01:24Parenteral Anesthetics: Overview
1.0K
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
1.0K
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
2.0K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
2.0K
01:29Local Anesthetics: Clinical Application as Epidural Anesthesia
1.0K
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
1.0K
01:24General Anesthesia: Overview
1.1K
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
1.1K