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Potential involvement of IL-17F in asthma
Kyoko Ota1, Mio Kawaguchi1, Satoshi Matsukura2
1Division of Clinical Medicine, Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan.
Journal of Immunology Research
|May 16, 2014
Summary
Interleukin-17F (IL-17F) drives allergic airway inflammation in asthma. A specific genetic variant, IL-17F H161R, acts as an antagonist, influencing disease severity and potentially offering therapeutic targets.
Area of Science:
- Immunology
- Genetics
- Respiratory Medicine
Background:
- Interleukin-17F (IL-17F) is expressed in asthmatic airways and linked to disease severity.
- IL-17F promotes allergic airway inflammation by inducing molecules like CCL20, which recruits Th17 cells.
Purpose of the Study:
- To investigate the role of IL-17F in asthma pathogenesis.
- To identify novel sources and signaling pathways of IL-17F.
- To examine the association of an IL-17F genetic variant with asthma.
Main Methods:
- Identified bronchial epithelial cells as a novel IL-17F source via the ST2-ERK1/2-MSK1 pathway.
- Analyzed a case-control study of 867 Japanese subjects for the IL-17F H161R variant.
- Assessed the association of the H161R variant with asthma and lung function (FEV1/FVC).
Main Results:
- Bronchial epithelial cells produce IL-17F in response to IL-33.
- The IL-17F H161R variant was associated with asthma in Japanese subjects.
- This variant showed a significant association with prebronchodilator FEV1/FVC in atopic asthma patients and acts as a natural antagonist.
Conclusions:
- IL-17F plays a significant role in allergic airway inflammation, airway remodeling, and steroid resistance in asthma.
- The IL-17F H161R variant influences asthma susceptibility and severity.
- IL-17F represents a potential therapeutic target for novel asthma treatments.
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