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Polymersomes as an effective drug delivery system for glioma--a review
Balakumar Krishnamoorthy1, Vamshikrishna Karanam, Vijaya Raghavan Chellan
1Department of Pharmaceutics, PSG College of Pharmacy , Peelamedu, Coimbatore, Tamil Nadu , India and.
Abstract:
Glioma is one of the most commonly occurring malignant brain tumours which need proper treatment strategy. The current therapies for treating glioma like surgical resection, radiotherapy, and chemotherapy have failed in achieving satisfactory results and this forms a rationale for the development of novel drug delivery systems. Among them, polymersomes are superior novel carriers with diverse functions like enhanced stability, low permeability, tunable membrane properties, surface functionality, and long blood circulation time which make them suitable for cancer therapy. These are bilayered vesicles capable of encapsulating both hydrophilic and hydrophobic drugs used to target glioma effectively. In this review, we have discussed on general preparation, characterization, and targeting aspects of surface modified polymersomes for effective delivery of therapeutic agents to glioma.
Insights
Novel polymersomes offer a promising solution for glioma treatment by effectively delivering therapeutic agents. These advanced drug delivery systems show potential for improved cancer therapy outcomes.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Oncology
Background:
- Glioma, a common malignant brain tumor, presents significant treatment challenges.
- Current therapies (surgery, radiotherapy, chemotherapy) often yield unsatisfactory results for glioma.
- There is a critical need for innovative drug delivery systems to improve glioma treatment efficacy.
Purpose of the Study:
- To review the preparation, characterization, and targeting of surface-modified polymersomes.
- To highlight polymersomes as advanced drug delivery vehicles for glioma therapy.
- To explore the potential of polymersomes in enhancing therapeutic agent delivery to brain tumors.
Main Methods:
- Review of literature on polymersome preparation and characterization.
- Discussion of surface modification strategies for targeted drug delivery.
- Analysis of polymersomes' properties relevant to cancer therapy.
Main Results:
- Polymersomes exhibit enhanced stability, controlled permeability, and tunable surface properties.
- They can encapsulate both hydrophilic and hydrophobic drugs for versatile therapeutic applications.
- Surface modification enables targeted delivery of therapeutic agents to glioma cells.
Conclusions:
- Polymersomes represent a superior class of novel carriers for glioma treatment.
- Their unique properties make them highly suitable for effective and targeted cancer therapy.
- Further development of surface-modified polymersomes holds significant promise for future glioma drug delivery strategies.
