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Cyberknife radiosurgery for cranial plasma cell tumor
Cetty Alafaci1, Giovanni Grasso, Alfredo Conti
1University of Messina, Department of Neurosurgery, Messina, Italy.
Turkish Neurosurgery
|May 17, 2014
Summary
Intracranial plasma cell tumors, rare initial signs of multiple myeloma, were successfully treated with CyberKnife radiosurgery. This technique precisely targeted lesions, achieving complete local control in a unique case of multifocal brain involvement.
Area of Science:
- Neuro-oncology
- Radiation Oncology
- Hematology
Background:
- Cranial and intracranial involvement by myelomatous disease is uncommon.
- Systemic manifestations of multiple myeloma typically accompany symptom onset in most cases.
- Intracranial plasma cell tumors can present as the initial manifestation of multiple myeloma.
Observation:
- A patient presented with multiple intracranial plasma cell tumor localizations as the first signs of multiple myeloma.
- The patient had lesions localized at the clivus and sella turcica.
- The case involved serial appearance of these intracranial localizations.
Findings:
- CyberKnife radiosurgery was employed to treat a lesion at the clivus and sella turcica.
- The treatment achieved complete local control of the targeted lesion.
- High-dose conformality allowed for an ablative radiation dose to the tumor while minimizing exposure to surrounding critical structures.
Implications:
- CyberKnife radiosurgery is a potentially advantageous treatment for localized intracranial plasma cell tumors due to their radiosensitivity.
- This case represents the first reported instance of successful CyberKnife radiosurgery for multifocal intracranial plasmacytoma.
- The findings suggest radiosurgery as a viable option for managing rare intracranial manifestations of multiple myeloma.
