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Estimated paediatric mortality associated with influenza virus infections, United States, 2003-2010

K K Wong1, P Cheng2, I Foppa2

  • 1Epidemic Intelligence Service assigned to Influenza Division,Centers for Disease Control and Prevention,Atlanta, GA,USA.

Epidemiology and Infection
|May 17, 2014
PubMed

Insights

Influenza deaths in US children are likely underestimated. This study found nearly twice as many pediatric deaths were attributable to influenza than officially reported, especially before the 2009 pandemic.

Area of Science:

  • Epidemiology
  • Public Health
  • Pediatric Mortality

Background:

  • Influenza-certified deaths on death certificates likely underestimate true pediatric influenza mortality.
  • Accurate estimation of influenza-attributable deaths is crucial for public health interventions.

Purpose of the Study:

  • To estimate the number of pediatric deaths attributable to influenza in the US.
  • To compare estimated influenza-attributable deaths with influenza-certified deaths.

Main Methods:

  • Utilized US mortality data for individuals under 18 years from 2003-2010.
  • Employed a generalized linear regression model incorporating seasonal factors, influenza-certified deaths, and pandemic periods.
  • Analyzed 32,783 pediatric deaths, identifying 853 (3%) as influenza-certified.

Main Results:

  • Estimated influenza-attributable deaths were 1.8 times higher than influenza-certified deaths overall.
  • During non-pandemic periods, attributable deaths were 2.1 times higher than certified deaths.
  • During the 2009 pandemic, attributable deaths were 1.1 times higher than certified deaths.

Conclusions:

  • US pediatric deaths attributed to influenza are significantly underreported by death certificates.
  • The discrepancy between estimated and certified deaths was more pronounced in non-pandemic seasons.
  • Findings highlight the need for improved surveillance and reporting of pediatric influenza mortality.

Keywords:
Influenzapaediatricspandemic

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