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Paraoxonase 1 activity in patients with chronic obstructive pulmonary disease
Lada Rumora1, Marija Grdić Rajković, Lara Milevoj Kopčinović
11Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb , Croatia.
COPD
|May 17, 2014
Summary
Paraoxonase 1 (PON1) activity and reduced thiol groups are significantly lower in chronic obstructive pulmonary disease (COPD) patients. Arylesterase activity (ARE) is a potential biomarker for COPD diagnosis.
Area of Science:
- Biochemistry
- Pulmonology
- Oxidative Stress Research
Background:
- Paraoxonase 1 (PON1) is an antioxidant enzyme linked to high-density lipoproteins (HDL).
- Chronic obstructive pulmonary disease (COPD) is associated with oxidative stress.
- Reduced thiol groups serve as indicators of protein oxidation.
Purpose of the Study:
- To investigate PON1 paraoxonase and arylesterase activities in COPD patients.
- To assess reduced thiol group concentrations in COPD patients.
- To evaluate PON1 activity as a potential biomarker for COPD.
Main Methods:
- Study included 105 stable COPD patients and 44 healthy controls.
- PON1 activities and thiol concentrations were measured using spectrophotometry on serum samples.
Main Results:
- COPD patients exhibited significantly reduced PON1 basal (POX) and salt-stimulated paraoxonase (POX1) activities, as well as arylesterase (ARE) activity.
- Reduced thiol group concentrations were significantly lower in the COPD group.
- ARE demonstrated strong discriminatory power between healthy individuals and COPD patients, indicating its potential as a COPD predictor.
Conclusions:
- Decreased PON1 activity in COPD may stem from an oxidative environment and oxidative changes to enzyme cysteine residues.
- Reduced PON1 arylesterase activity might suggest down-regulation of PON1 concentration.
- Arylesterase activity shows promise as a potential biomarker for diagnosing COPD.
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