Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inflammation

Inflammation

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Heart Rate Variability During Exercise-Heat Stress Following Seven Days of Passive Heat Acclimation in Older Males: A Secondary Analysis.

Medicine and science in sports and exercise·2026

Same author

Phase-Dependent Autonomic Responses to Electric Fan Use During a Prolonged 8-hour Heat Exposure in Older Adults.

American journal of physiology. Regulatory, integrative and comparative physiology·2026

Same author

Does Consuming Fresh Ultraviolet Light-Exposed Mushrooms Offset the Seasonal Decline in Serum Total 25OHD in Adults Classified as Overweight and Class I Obese? Results from a Randomized Controlled Trial.

Foods (Basel, Switzerland)·2026

Same author

Examining widely held propositions on human dietary protein needs and benefits: a critical review of the science that shapes both the data and our understanding of an essential macronutrient.

Critical reviews in food science and nutrition·2026

Same author

Metastasis suppressing properties of the cell-surface anchored serine protease prostasin: new functional and mechanistic insights from breast cancer.

Oncogenesis·2026

Same author

Nutrition for Older Adults: Perspectives on Dietary Guidance for Healthy Aging.

Current developments in nutrition·2026

Same journal

Short-term endurance training in the cold with layered clothing mitigates perceptual strain during exercise in the heat.

European journal of applied physiology·2026

Same journal

Sex comparisons across different indices of vascular health in recreationally active healthy adults.

European journal of applied physiology·2026

Same journal

Moderate altitude-mimicking CO-induced inhibition of hemoglobin oxygen binding decreased middle-distance swimming speed in male national-level swimmers.

European journal of applied physiology·2026

Same journal

Kinetics of submaximal DFA α1 prior and post maximal efforts in trained and highly trained male and female cyclists.

European journal of applied physiology·2026

Same journal

Effects of normobaric hypoxia and hyperthermia on ventilatory responses to high-intensity interval training bouts.

European journal of applied physiology·2026

Same journal

Does creatine supplementation improve strength and power in physically active individuals on a vegan diet? a randomized, triple-blind, placebo-controlled trial.

European journal of applied physiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 29, 2026

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

Resistance exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage without

Melissa M Markofski¹, Michael G Flynn, Andres E Carrillo

¹Sealy Center on Aging, University of Texas Medical Branch at Galveston, 301 University St., Galveston, TX, 77555-0177, USA, memarkof@utmb.edu.

European Journal of Applied Physiology

|May 17, 2014

Summary

This summary is machine-generated.

Resistance training effectively reduces systemic inflammation in older, overweight adults. This exercise intervention lowered inflammatory monocyte percentages and improved disease risk biomarkers, independent of weight loss.

More Related Videos

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Related Experiment Videos

Last Updated: Apr 29, 2026

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Area of Science:

Gerontology
Exercise Physiology
Immunology

Background:

Systemic inflammation is a hallmark of aging and obesity, contributing to chronic disease risk.
Exercise training is known to reduce inflammation in weight-stable individuals.
The impact of concurrent diet-induced weight loss on exercise-mediated inflammation reduction is less understood.

Purpose of the Study:

To investigate the effects of resistance training on inflammatory markers in older, overweight adults.
To determine if resistance training reduces inflammatory monocyte percentage and improves disease risk biomarkers.
To assess whether these effects are independent of concurrent diet-induced weight loss.

Main Methods:

Forty physically inactive, overweight adults (age 58.0 ± 5.7 years, BMI 30.1 ± 4.3 kg/m²) underwent 12 weeks of resistance training.
Participants were assigned to either a weight-maintenance diet (RE, n=14) or an energy-restricted diet (RE-ER, n=12).
A comparison group of nine physically active adults (age 60.1 ± 6.1 years, BMI 25.8 ± 3.1 kg/m²) was included.

Main Results:

Baseline inflammatory markers (CD14+CD16+ monocytes, C-reactive protein, cholesterol) were higher in physically inactive vs. active individuals.
Resistance training (RE) significantly decreased circulating CD14+CD16+ monocyte percentage by ~35%.
Both RE and RE-ER groups showed reduced lipopolysaccharide (LPS)-stimulated TNFα and IL-6 production; RE-ER additionally showed lower cholesterol.

Conclusions:

Resistance training is a potent strategy for reducing systemic inflammation in older, overweight adults.
The observed anti-inflammatory effects of resistance training appear independent of significant weight loss.
Further research is warranted to optimize combined resistance training and dietary interventions for inflammation management.