Related Experiment Video
Updated: Apr 29, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
Modeling US adult obesity trends: a system dynamics model for estimating energy imbalance gap
Saeideh Fallah-Fini1, Hazhir Rahmandad, Terry T-K Huang
1At the time of the study, Saeideh Fallah-Fini was with Johns Hopkins Global Center on Childhood Obesity, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. Hazhir Rahmandad is with the Industrial and Systems Engineering Department, Virginia Tech, Falls Church, VA. Terry T.-K. Huang is with Department of Health Promotion, Social and Behavioral Health, University of Nebraska Medical Center, College of Public Health, Omaha. Regina M. Bures is with Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. Thomas A. Glass is with Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health. Regina M. Bures is also a guest editor for this theme issue.
Objectives:
We present a system dynamics model that quantifies the energy imbalance gap responsible for the US adult obesity epidemic among gender and racial subpopulations.
Methods:
We divided the adult population into gender-race/ethnicity subpopulations and body mass index (BMI) classes. We defined transition rates between classes as a function of metabolic dynamics of individuals within each class. We estimated energy intake in each BMI class within the past 4 decades as a multiplication of the equilibrium energy intake of individuals in that class. Through calibration, we estimated the energy gap multiplier for each gender-race-BMI group by matching simulated BMI distributions for each subpopulation against national data with maximum likelihood estimation.
Results:
No subpopulation showed a negative or zero energy gap, suggesting that the obesity epidemic continues to worsen, albeit at a slower rate. In the past decade the epidemic has slowed for non-Hispanic Whites, is starting to slow for non-Hispanic Blacks, but continues to accelerate among Mexican Americans.
Conclusions:
The differential energy balance gap across subpopulations and over time suggests that interventions should be tailored to subpopulations' needs.
More Related Videos
Related Concept Videos
Modeling with Differential Equations
Clearance Models: Physiological Models
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
Energy Balance
Obesity
Exponential Equations for Modeling Growth
Clearance Models: Noncompartmental Models
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...

