Changes in lung function in older people from the English Longitudinal Study of Ageing

Decline in lung function with increasing age is common in older people. However, the rate of decline using the forced expiratory volume in 1 s (FEV1) in a longitudinal study in the elderly community dwellers is unknown.

We analyzed data from the English Longitudinal Study of Ageing on people 50 years and older who had FEV1 measurement at Wave 2 and Wave 4 of 4 years of follow-up, respectively. A random coefficient model was employed to examine the changes in FEV1 and predict differences in the levels of FEV1 in older people.

A total of 4224 participants were included in the study. The mean (± standard deviation [SD]) rate of change in FEV1 was a decline of 32.92 ± 0.96 ml/year. The absolute difference in mean FEV1 level between female and male participants was 767.07 ± 16.6 ml. It was 253.91 ± 22.7 ml lower in current smokers than in nonsmokers, 73.67 ± 18.67 ml lower in participants with a history of sputum in winter months than in participants without sputum, 63.32 ± 7.07 ml lower in participants with a higher dyspnea score than in participants with a lower dyspnea score and 67.77 ± 15.87 ml higher in participants with good health compared to participants with fair/poor health status. One microgram increase in C-reactive protein level lowered FEV1 by 4.66 ± 0.86 ml and one Hb of hemoglobin increased the FEV1 level by 4.78 ± 0.77 ml. All were statistically significant at p < 0.001.

The average rate of FEV1 decline in older people without respiratory diseases was found to be high. Lower level of FEV1 was also observed in current smokers, females, those with a history of sputum in winter months and in participants with higher dyspnea score or in those with poorer health status.