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Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
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FoxO mediates APP-induced AICD-dependent cell death.

X Wang1, Z Wang1, Y Chen2

  • 11] Department of Interventional Radiology, Shanghai 10th People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, China [2].

Cell Death & Disease
|May 17, 2014
PubMed
Summary

Alzheimer's disease protein APP triggers cell death via its AICD fragment, which interacts with the FoxO protein. This interaction promotes the transcription of cell death genes, highlighting a new pathway in AD pathogenesis.

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