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Panton-Valentine Leukocidin-positive Staphylococcus aureus: a potentially significant pathogen in cystic fibrosis

Peter J Barry1, Barbara J Isalska2, Andrew M Jones3

  • 1Manchester Adult Cystic Fibrosis Centre, University Hospital of South Manchester, Wythenshawe, Manchester, M23 9LT, UK.

Paediatric Respiratory Reviews
|May 17, 2014
PubMed

Insights

Staphylococcus aureus, particularly strains producing Panton-Valentine Leukocidin (PVL), can cause severe pneumonia in cystic fibrosis patients. This case highlights potential transmission from healthy carriers and reviews PVL

Area of Science:

  • Medical Microbiology
  • Pulmonary Medicine
  • Infectious Diseases

Background:

  • Staphylococcus aureus is a significant pathogen in cystic fibrosis (CF) lung disease.
  • Panton-Valentine Leukocidin (PVL) toxin is associated with severe necrotizing pneumonia in healthy individuals.
  • PVL-producing S. aureus strains have been detected in CF patients.
Keywords:
Cystic fibrosisInfection controlPVLPneumoniaStaphylococcus aureus

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