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Updated: Apr 29, 2026
Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
Highly selective colorimetric/fluorometric dual-channel fluoride ion probe, and its capability of differentiating
Xujun Zheng1, Wencheng Zhu, Dong Liu
1Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, §National Engineering Research Center for Biomaterials, and #College of Materials Science and Engineering, Sichuan University , Chengdu 610064, P. R. China.
Abstract:
A dual-channel naphthalimide-based chemosensor for rapid and sensitive detection of fluoride ion has been developed. Upon addition of F(-), it undergoes deprotonation reaction through H-bonding interactions, and its maximum absorption wavelength is red-shifted for 214 nm to the far-red region, together with drastically quenched fluorescence. In addition, it shows high selectivity toward F(-) anion, thus could be used for practical applications to detecting F(-) in both solution and solid state. Furthermore, the fluorescence of NIM could be enhanced in protein-containing acidic environments, hence NIM could act as lysosome marker to differentiate cancer cells from normal ones in cell imaging.
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