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In vitro high throughput screening, what next? Lessons from the screening for aurora kinase inhibitors

Thi-My-Nhung Hoang1, Hong-Lien Vu2, Ly-Thuy-Tram Le3

  • 1INSERM UJF U823 Institut Albert Bonniot, Team 4: Chromatin and Epigenetic, BP 170, 38 042 Grenoble Cedex 9, France. hoangthimynhung@hus.edu.vn.

Biology
|May 17, 2014
PubMed

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...