Platelet parameters in healthy and pathological pregnancy

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Clinical Pathology

Background:

• Platelet count (PLT) changes are common and critical during pregnancy, with reduced PLT being the most frequent hemostasis abnormality.
• Numerous platelet disorders in pregnancy share clinical and laboratory features, complicating accurate diagnosis.
• Understanding reference intervals for platelet parameters in pathological pregnancies is essential for maternal and fetal well-being.

Purpose of the Study:

• To establish reference intervals for platelet parameters in specific pregnancy pathologies: pre-eclampsia, gestational diabetes, autoimmune disorders, and viral infections.
• To compare platelet parameter differences between healthy and pathological pregnancies.
• To assess the utility of the Sysmex XE-2100 automated hematology analyzer in evaluating these changes.

Main Methods:

• Analysis of 100 pregnant women in their third trimester.
• Measurement of platelet count (PLT), platelet distribution width, and mean platelet volume (MPV) using the Sysmex XE-2100 analyzer.
• Comparison of parameters between healthy pregnant women and those with pre-eclampsia, gestational diabetes, autoimmune disorders, or viral infections.

Main Results:

• Statistically significant differences in PLT were observed in pre-eclampsia, autoimmune disorders, and viral infections compared to healthy pregnancies.
• Statistically significant differences in MPV were found in pre-eclampsia and gestational diabetes.
• The study identified key hematologic changes associated with specific pregnancy pathologies.

Conclusions:

• Complete blood count parameters, including PLT and MPV, can effectively detect hematologic changes in pathological pregnancies.
• These findings support the use of simple complete blood count tests for managing complex pregnancy conditions.
• Accurate diagnosis and management of pregnancy-related platelet disorders necessitate close collaboration between clinical and laboratory specialists.