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Updated: Apr 29, 2026
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Published on: September 27, 2024
Does the prognosis of colorectal cancer vary with tumor site?
Mohamad Asghari Jafarabadi1, Seyede Momeneh Mohammadi2, Ebrahim Hajizadeh3
1National Public Health Management Center(NPMC) and Department of Statistics and Epidemiology, School of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Aim:
The aim of this study was to compare prognostic factors between colon and rectal cancers.
Background:
Prognosis of Colorectal Cancer (CRC) may depend on the anatomical site.
Patients And Methods:
A total of 1219 patients with CRC diagnosis according to the pathology report of RCGLD cancer registry, from 1 January 2002 to 1 October 2007, were entered into the study. Demographic and clinico-pathological factors were analyzed using survival analysis.
Results:
From age at diagnosis, colon cancer had significantly better survival than rectal cancer (Multivariate Hazard Ratio (MVHR)=0.24; 95% Confidence Interval (CI) =(0.074-0.77)). Other factors, including marital status (MVHR =1.78; 95% CI =(0.33-9.62)), body mass index (BMI) (MVHR =1.21 and 1.54; 95% CI =(.30-4.85) and (.44-5.4) respectively for < 18.5 and >30 BMI groups), pathologic stage (MVHR =.64; 95% CI =(.21-1.98)) and alcohol history (MVHR =4.86; 95% CI =(.67-35.14)) were not significantly different between the two patient group but suggested a possible effect upon prognosis. Overall survival in rectum was better than that of colon.
Conclusion:
Our findings support this hypothesis that prognosis of CRC varies with tumor site.
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