Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.7K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.7K
Glucose Transporters01:27

Glucose Transporters

15.2K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
15.2K
Autoimmune Disorders01:29

Autoimmune Disorders

2.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

900
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
900
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

45
Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1...
45
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

1.1K
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From heterogeneity to mechanism: a systems-level analysis pinpoints the S100A8/A9 axis in colorectal cancer.

Cancer cell international·2026
Same author

Beyond the stomach: Exploring the role of <i>Helicobacter pylori</i> in pushing precancerous lesions to colorectal cancer and the therapeutic potential of probiotics.

Expert reviews in molecular medicine·2026
Same author

Surface-Engineered Selenium Nanoparticles with L-Asparagine and Tartaric Acid: Therapeutic Efficacy Against Breast Cancer and Bacterial Infections.

Iranian journal of medical sciences·2026
Same author

Antimicrobial and antioxidant properties of green synthesis CuO nanoparticles using <i>Salvia officinalis</i> hydroalcoholic extract.

Iranian journal of microbiology·2026
Same author

Evaluation of E-Cigarette Effects on Gene Expression Profile of Human Bronchial Epithelial Cells: A System Biology Approach.

Tanaffos·2026
Same author

Beyond Antibiotics: Alternative Strategies Targeting <i>Helicobacter pylori</i> Resistance.

Expert reviews in molecular medicine·2026

Related Experiment Video

Updated: Apr 29, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

23.9K

Gluten related disorders.

Mohammad Rostami Nejad1, Maryam Karkhane1, Abdolrazagh Marzban2

  • 1Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical sciences, Tehran, Iran.

Gastroenterology and Hepatology From Bed to Bench
|May 17, 2014
PubMed
Summary
This summary is machine-generated.

Gluten sensitivity (GS) and celiac disease (CD) are gluten-related disorders. This review focuses on non-celiac gluten sensitivity, discussing its clinical presentation and diagnostic challenges.

Keywords:
Celiac diseaseDifferentiationGluten sensitivityHistology

More Related Videos

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models
07:39

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

Published on: September 1, 2023

2.1K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

6.7K

Related Experiment Videos

Last Updated: Apr 29, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

23.9K
Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models
07:39

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

Published on: September 1, 2023

2.1K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

6.7K

Area of Science:

  • Gastroenterology
  • Immunology
  • Internal Medicine

Background:

  • Gluten-related disorders are increasingly recognized, often presenting with diverse symptoms.
  • Celiac disease (CD) involves small intestinal villi destruction due to gluten in genetically susceptible individuals.
  • Non-celiac gluten sensitivity (GS) presents similarly to CD but lacks specific antibodies and histological damage.

Purpose of the Study:

  • To review the clinical presentation of non-celiac gluten sensitivity.
  • To explore current and future diagnostic approaches for non-celiac GS.

Main Methods:

  • Literature review of studies on gluten sensitivity and celiac disease.
  • Analysis of clinical manifestations and diagnostic criteria.

Main Results:

  • Non-celiac GS is characterized by a wide range of symptoms, both intestinal and extra-intestinal.
  • Diagnostic pathways for non-celiac GS remain challenging due to the absence of definitive biomarkers.
  • Established associations exist between CD and other disorders, but less is known about coexistent conditions with GS.

Conclusions:

  • Further research is needed to clarify the pathophysiology and establish reliable diagnostic methods for non-celiac GS.
  • Understanding the clinical spectrum of non-celiac GS is crucial for accurate diagnosis and management.
  • Differentiating non-celiac GS from CD and other conditions requires careful clinical evaluation.