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Living related donor liver transplantation in Iranian children: a 12- year experience
Najmeh Haseli1, Jafar Hassanzade1, Seyed Mohsen Dehghani2
1Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
Insights
Living Related Donor Liver Transplantation (LRDLT) offers a life-saving option for children with liver disease. Key factors influencing survival in pediatric LRDLT patients include weight, PELD/MELD score, and post-transplant complications.
Area of Science:
- Pediatric Hepatology
- Transplantation Surgery
- Clinical Outcomes Research
Background:
- Living Related Donor Liver Transplantation (LRDLT) is a critical intervention for pediatric patients with end-stage liver disease.
- This technique provides a viable alternative when deceased donor organs are unavailable, offering a chance for extended life.
Purpose of the Study:
- To evaluate the outcomes and survival rates of pediatric patients (<18 years) undergoing their first LRDLT.
- To identify factors influencing patient survival following LRDLT in this cohort.
Main Methods:
- A historical cohort study was conducted on 191 pediatric patients who underwent their initial LRDLT.
- Kaplan-Meier analysis was used to assess survival rates.
- Univariate and multivariate analyses examined the impact of recipient, donor, and procedural factors on survival.
Main Results:
- Overall survival rates at 1, 3, 5, and 11 years were 71%, 66%, 65%, and 65%, respectively.
- Univariate analysis identified age, weight at transplantation, PELD/MELD score, and post-transplant complications as significant factors.
- Multivariate analysis confirmed weight at transplantation, PELD/MELD score, and post-transplant complications as independent prognostic variables.
Conclusions:
- LRDLT is an established procedure with acceptable outcomes at the study center.
- While overall survival rates are lower than some reported series, 1-month post-transplant survival is comparable, indicating successful early outcomes.
Aim:
The aim of this study was to describe our results and investigate the survival of below-18-year-old patients undergoing LRDLT and the factors affecting this.
Background:
Living Related Donor Liver Transplantation (LRDLT) has become a good option to provide suitable grafts for children with liver diseases. Using this method, children who have no chance for life can live a much longer life.
Patients And Methods:
The present study is a historical cohort study carried on 191 patients below-18-year-sold who had undergone LRDLT for the first time in the Namazi hospital liver transplantation center. Survival rate of the patients was assessed using Kaplan-Meier method. The effect of factors related to the recipients, donors, and the transplantation process on the patients' survival was also investigated.
Results:
1, 3, 5 and 11-year survival of patients was 71%, 66%, 65%, and 65%, respectively. In the univariate analysis, age, weight at transplantation, PELD/MELD score, existence of post-transplant complications were found to be effective factors on the patients' survival. In the multivariate analysis, weight at transplantation, PELD/MELD score, and existence of post-transplant complications were the prognostic variables.
Conclusion:
LRDLT is now well established with satisfactory results in our center. Although the survival rate of the patients is lower than the survival rate reported in other studies, but the survival of the patients who had survived 1 month after the transplantation was comparable to other studies.
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