Related Experiment Video

Updated: Apr 29, 2026

Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow
05:43

Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow

Published on: January 13, 2017

15.3K

Methemoglobinemia induced by lidocaine-prilocaine cream

Oded Shamriz, Inbal Cohen-Glickman, Shimon Reif

    The Israel Medical Association Journal : IMAJ
    |May 20, 2014
    PubMed

    More Related Videos

    Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid04:12

    Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

    Published on: January 19, 2024

    2.1K
    Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ10:05

    Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

    Published on: May 8, 2020

    1.8K

    Related Concept Videos

    Local Anesthetics: Common Agents and Their Applications01:23

    Local Anesthetics: Common Agents and Their Applications

    Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
    Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
    1.3K
    Local Anesthetics: Chemistry and Structure-Activity Relationship01:30

    Local Anesthetics: Chemistry and Structure-Activity Relationship

    Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
    4.9K
    Local Anesthetics: Adverse Effects01:12

    Local Anesthetics: Adverse Effects

    While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
    Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
    1.0K
    Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

    Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

    Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
    2.8K
    Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

    Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

    Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
    One of the advantages of...
    2.2K
    Local Anesthetics: Mechanism of Action01:23

    Local Anesthetics: Mechanism of Action

    Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
    Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
    4.4K