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Red cell distribution width predicts contrast-induced nephropathy in patients undergoing percutaneous coronary
Alparslan Kurtul1, Mikail Yarlioglues2, Sani Namik Murat2
1Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey alpkurtul@yahoo.com.
Insights
Elevated red cell distribution width (RDW) is linked to a higher risk of contrast-induced nephropathy (CIN) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). This finding may help identify at-risk individuals.
Area of Science:
- Cardiology
- Nephrology
- Clinical Medicine
Background:
- Contrast-induced nephropathy (CIN) is a complication following percutaneous coronary intervention (PCI).
- Predictive markers for CIN in acute coronary syndrome (ACS) patients are crucial for risk stratification.
Purpose of the Study:
- To investigate the association between red cell distribution width (RDW) and the incidence of CIN.
- To identify RDW as a potential independent risk factor for CIN in ACS patients undergoing PCI.
Main Methods:
- A cohort of 662 ACS patients undergoing PCI was retrospectively analyzed.
- Patients were categorized into CIN and no-CIN groups based on serum creatinine changes post-PCI.
- Multivariate regression analysis was employed to determine independent risk factors for CIN.
Main Results:
- CIN developed in 12.2% of patients.
- Higher baseline RDW, creatinine, and high-sensitivity C-reactive protein levels were observed in the CIN group.
- Increased RDW was an independent risk factor for CIN (OR 1.379, P = .009).
Conclusions:
- Elevated baseline RDW is independently associated with an increased risk of CIN in ACS patients undergoing PCI.
- RDW may serve as a valuable biomarker for predicting CIN development.
- Further research is warranted to explore the underlying mechanisms and clinical implications.
Abstract:
We investigated the relationship between red cell distribution width (RDW) and contrast-induced nephropathy (CIN) in patients (aged 61 ± 12, 69% men) with acute coronary syndrome (ACS). Consecutive patients diagnosed with ACS (n = 662) who underwent percutaneous coronary intervention (PCI) were included in the study. Patients were divided into 2 groups: CIN and no CIN. Contrast-induced nephropathy was defined as an increase in serum creatinine level of ≥0.5 mg/dL or ≥25% above baseline within 72 hours after PCI. Contrast-induced nephropathy occurred in 81 (12.2%) patients. Red cell distribution width, creatinine, and high-sensitivity C-reactive protein levels were significantly higher in the CIN group than in the no-CIN group. Multivariate regression analysis revealed that baseline RDW level (odds ratio 1.379, 95% confidence interval 1.084-1.753, P = .009), age (P = .025), creatinine (P = .004), and left ventricular ejection fraction (P = .011) were independent risk factors for the development of CIN. In conclusion, increased RDW levels are independently associated with a greater risk of CIN in patients undergoing PCI for ACS.
