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[Prophylaxis in severe congenital neonatal varicella. Apropos of two cases]
F Rubio Quiñones1, J A García Hernández, E Iglesias Maqueda
1Servicio de Neonatología, Hospital Infantil, Centro Sanitario, Virgen del Rocío Sevilla.
Anales Espanoles De Pediatria
|December 1, 1989
Insights
Severe neonatal varicella complications occurred in newborn twins despite receiving zoster immunoglobulin (ZIG) prophylaxis. This highlights the need to re-evaluate current prophylaxis criteria for newborns at risk of severe varicella.
Area of Science:
- Virology
- Immunology
- Neonatal Medicine
Context:
- Neonatal varicella poses a significant risk of severe complications.
- Human anti-chickenpox immunoglobulin (zoster immunoglobulin, ZIG) is used for prophylaxis.
Purpose:
- To report two cases of neonatal varicella in twins with severe complications despite ZIG prophylaxis.
- To discuss and potentially revise current criteria for ZIG prophylaxis in at-risk newborns.
Summary:
- Two cases of neonatal varicella in twins are presented, both experiencing serious complications.
- Prophylaxis with ZIG did not prevent severe outcomes in these neonates.
- The cases suggest limitations in current ZIG prophylaxis guidelines for preventing severe neonatal varicella.
Impact:
- Findings may lead to updated guidelines for ZIG prophylaxis in newborns.
- Highlights the need for further research into effective preventative strategies for neonatal varicella.
- Emphasizes the potential severity of neonatal varicella even with prophylactic treatment.
Abstract:
We present two cases of neonatal varicella in newborn twins, who had serious complications in spite of being given human anti-chickenpox immuneglobulin (zoster immuneglobulin ZIG) prophylaxis. We comment on current criteria of the prophylaxis in newborns with risk of severe neonatal varicella.