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[Pneumonitis induced by amiodarone].

M Terra Filho, F S Vargas, A Cukier

    Arquivos Brasileiros De Cardiologia
    |October 1, 1989
    PubMed
    Summary

    Amiodarone can cause serious lung disease, with symptoms like shortness of breath and cough. Discontinuing the drug and using corticosteroids may improve outcomes for patients with amiodarone-induced pulmonary disease.

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    Respiratory medicine·2007

    Area of Science:

    • Pulmonology
    • Cardiology
    • Pharmacology

    Context:

    • Amiodarone is a widely used antiarrhythmic drug.
    • Amiodarone-induced pulmonary disease (AIPD) is a rare but serious adverse effect.
    • Early diagnosis and management are crucial for patient outcomes.

    Purpose:

    • To investigate the clinical characteristics, diagnostic findings, and outcomes of patients with amiodarone-induced pulmonary disease.
    • To evaluate the efficacy of discontinuing amiodarone and initiating corticosteroid therapy.

    Summary:

    • Fifteen patients with AIPD were studied, with a mean age of 64.0 years.
    • Common symptoms included progressive dyspnea and cough, with characteristic radiographic findings of bilateral interstitial infiltrates.
    • Lung function tests revealed restrictive ventilatory insufficiency and hypoxemia.

    Impact:

    • Amiodarone discontinuation and corticosteroid treatment led to improvement in eight patients, while five patients died.
    • This study highlights the importance of recognizing and managing amiodarone-induced pulmonary disease.
    • Findings contribute to understanding the clinical spectrum and management strategies for this iatrogenic condition.

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