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Area of Science:

  • Cardiovascular Surgery
  • Thoracic Surgery
  • Vascular Surgery

Background:

  • The established benefit of internal thoracic artery (ITA) sequential bypass grafting to single or bilateral ITA grafts for enhanced arterial revascularization remains unclear.
  • Coronary artery bypass grafting (CABG) is a common surgical procedure for treating coronary artery disease.

Purpose of the Study:

  • To evaluate the safety and efficacy of ITA sequential bypass grafting in coronary artery surgery.
  • To compare outcomes between single and bilateral ITA grafting strategies, with and without sequential bypass.

Main Methods:

  • Retrospective review of 1,400 patients undergoing off-pump CABG for multivessel disease.
  • Patients were categorized into four groups: single ITA alone, single ITA with sequential, bilateral ITA alone, and bilateral ITA with sequential.
  • Analysis included assessment of complete revascularization, perioperative outcomes, and long-term survival.

Main Results:

  • Bilateral ITA grafting was associated with improved overall survival and reduced major adverse cardiac events (MACE) compared to single ITA grafting.
  • No significant difference in complete revascularization, perioperative mortality, or myocardial infarction rates was observed across groups.
  • Adding sequential ITA bypass grafting did not significantly improve survival or MACE-free survival in either single or bilateral ITA configurations.

Conclusions:

  • Bilateral ITA grafting demonstrates superior long-term survival benefits in patients undergoing off-pump CABG for multivessel disease.
  • While safe, the addition of sequential ITA bypass grafting does not confer additional survival advantages.
  • These findings support the use of bilateral ITA grafting for improved patient outcomes in specific CABG scenarios.