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Effects of tachykinins on mucus secretion in human bronchi in vitro
D F Rogers1, B Aursudkij, P J Barnes
1Department of Thoracic Medicine, National Heart and Lung Institute, London, U.K.
European Journal of Pharmacology
|December 19, 1989
Abstract:
We examined the effects of mammalian tachykinins on human bronchial secretion in vitro using fucose as an endogenous marker for mucus. Substance P (SP, 10(-9)-10(-5) M) increased secretion in a dose-related manner and was more potent than neurokinin A or neurokinin B. The enkephalinase (endopeptidase 24.11) inhibitor phosphoramidon (10(-5) M) potentiated the effect of SP (10(-7) M). SP is a potent stimulant of secretion in human bronchi and enkephalinase may modulate its effects.