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Optimization of ketone-based P2Y(12) receptor antagonists as antithrombotic agents: pharmacodynamics and receptor

Fabrizio Giordanetto1, Peter Bach1, Fredrik Zetterberg1

  • 1Medicinal Chemistry, CVMD iMed, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.

Bioorganic & Medicinal Chemistry Letters
|May 20, 2014
PubMed

Keywords:
Acute coronary syndrome (ACS)Acyl sulfonamidesEstersKetonesP2Y(12) receptorPiperidinyl-pyridinesPlatelet aggregationReceptor kineticsThromboembolism

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