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Updated: Feb 17, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Novel poly(NIPA-co-AAc) functional hydrogels with potential application in drug controlled release
Julio César Cuggino1, Cintia Belén Contreras, Alvaro Jimenez-Kairuz
1IMBIV-CONICET, Departamento de Química Orgánica, ‡UNITEFA-CONICET, Departamento de Farmacia, §CIBICI-CONICET, Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Haya de la Torre y Medina Allende, Edificio de Ciencias II, Ciudad Universitaria, Córdoba X5000HUA, Argentina.
Abstract:
The synthesis, characterization and properties of pH/thermosensitive hydrogels based on acrylic acid (AAc) and N-isopropylacrylamide (NIPA) using (+)-N,N'-diallyltartramide (DAT) as cross-linking agent and water as solvent, are presented in this article. Subsequently, the incorporation of ofloxacin (OFL) as model drug to evaluate the drug load capacity of hydrogels and the in vitro release from OFL-polymer conjugate are presented in order to define potential pharmaceutical applications. Interestingly, the incorporation of AAc diversified the properties of NIPA-based hydrogels allowing ionic interaction of these new materials with drugs of opposite charge and produced different release profiles at pH 1.2 and 6.8 simulated physiological media.
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