Related Experiment Video
Updated: Apr 29, 2026

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders
Published on: October 4, 2022
The effects of powder compressibility, speed of capsule filling and pre-compression on plug densification
Marcos Llusa1, Eva Faulhammer1, Stefano Biserni2
1Research Center Pharmaceutical Engineering GmbH, A-8010 Graz, Austria.
Abstract:
This paper describes the effect of powder compressibility and two process parameters of a dosator nozzle capsule filling machine on powder densification during plug formation. One process parameter was the ratio between the powder bed's depth and the length of the nozzle dosing chamber, hereinafter referred to as F. The other one was the speed of capsule filling. This paper demonstrates that powder densification during the capsule filling process is a function of the powder compressibility and the above process parameters (increasing them leads to higher plug density). The Walker model was used to characterize the compressibility of powders at low compression forces and the obtained compressibility coefficient W proved to be a good predictor of powder densification during the capsule filling process.
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Compacting Factor test
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Density, Specific Weight, Specific Gravity and Compressibility of Fluid
Specific weight represents the weight per unit volume and is calculated by multiplying...
Pore Size Distribution
Adequate...

