Related Experiment Video

Updated: Apr 29, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

10.5K

Ischemic placental disease and risks of perinatal mortality and morbidity and neurodevelopmental outcomes

Cande V Ananth1, Alexander M Friedman2

  • 1Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.

Seminars in Perinatology
|May 20, 2014
PubMed

Insights

Ischemic placental disease, including preeclampsia and growth restriction, elevates risks for stillbirth, infant mortality, and neurodevelopmental issues. These risks are most pronounced in preterm infants, highlighting the need for clinical interventions.

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Neonatal Health

Background:

  • Preeclampsia, intrauterine growth restriction, and placental abruption are severe obstetric complications.
  • These conditions collectively form the syndrome of ischemic placental disease.
  • Ischemic placental disease significantly contributes to perinatal morbidity and mortality.

Purpose of the Study:

  • To review the risks of stillbirth, neonatal, and infant mortality associated with ischemic placental disease.
  • To examine the risks of neonatal morbidity and neurodevelopmental outcomes in relation to ischemic placental disease.
  • To synthesize findings from population-based studies on adverse perinatal outcomes.

Main Methods:

  • Literature review focusing on population-based studies.
  • Synthesis of existing research on ischemic placental disease and perinatal outcomes.
  • Analysis of risks for mortality and neurodevelopmental deficits.

Main Results:

  • Each of the three complications, despite low prevalence, is linked to increased risks of adverse perinatal and infant outcomes.
  • Neurodevelopmental deficits are also associated with these conditions.
  • The heightened perinatal risks are most significant during the preterm period.

Conclusions:

  • Ischemic placental disease poses substantial risks to perinatal and infant health, including neurodevelopmental issues.
  • Preterm birth exacerbates the adverse outcomes associated with ischemic placental disease.
  • Developing effective clinical interventions to reduce the risks of ischemic placental disease is crucial.

Keywords:
Intrauterine growth restrictionIschemic placental diseaseNeurodevelopmental outcomesPerinatal mortalityPlacental abruptionPreeclampsiaStillbirth

More Related Videos

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.4K
A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

10.1K

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.2K
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
53
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.9K
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
40
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
40.2K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.8K