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Prediction and prevention of ischemic placental disease

Alexander M Friedman1, Kirsten L Cleary1

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

Seminars in Perinatology
|May 20, 2014
PubMed

Insights

Ischemic placental disease (IPD) encompasses preeclampsia, intrauterine growth restriction, and placental abruption. Early interventions, including aspirin and novel treatments, aim to prevent IPD and preterm birth, improving maternal and neonatal outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Neonatology

Background:

  • Ischemic placental disease (IPD) includes preeclampsia, intrauterine growth restriction (IUGR), and placental abruption.
  • These conditions share risk factors and pathophysiological processes, contributing to indicated preterm birth and neonatal complications.
  • IPD is a significant cause of preterm delivery, impacting neonatal morbidity and mortality.

Purpose of the Study:

  • To review current research on preventing preeclampsia and IUGR with aspirin.
  • To examine evidence for other medical interventions to prevent IPD.
  • To discuss novel interventions and clinical recommendations for IPD prevention.

Main Methods:

  • Literature review of studies on aspirin for preeclampsia and IUGR prevention.
  • Analysis of research on various medical interventions for IPD.
  • Evaluation of ongoing clinical trials, including statins, and current guidelines.

Main Results:

  • The role of aspirin in preventing preeclampsia and IUGR is complex and requires further research.
  • Evidence for other medical interventions in preventing IPD is being investigated.
  • New strategies, such as statins, are under clinical investigation for IPD prevention.

Conclusions:

  • Effective prevention of IPD and associated preterm birth is crucial for improving maternal and neonatal health.
  • Continued research into aspirin, other medical interventions, and novel therapies is essential.
  • Updated clinical recommendations are needed to guide the prevention of ischemic placental disease.

Keywords:
Indicated preterm birthIschemic placental diseasePreeclampsia prevention

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