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Related Experiment Videos

Fluorescence microlymphography in chronic venous incompetence.

A Bollinger1, G Pfister, U Hoffmann

  • 1Department of Internal Medicine, University Hospital, Zürich, Switzerland.

International Angiology : a Journal of the International Union of Angiology
|October 1, 1989
PubMed
Summary

Severe chronic venous incompetence damages superficial lymphatic capillaries, leading to indurated edema. This lymphatic microangiopathy involves capillary destruction and increased permeability, contributing to swelling in the ankle region.

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Area of Science:

  • Vascular biology
  • Dermatology
  • Lymphatic system research

Background:

  • Severe chronic venous incompetence affects both blood and lymphatic capillaries.
  • Superficial lymphatic capillaries in the medial ankle region are particularly vulnerable.

Purpose of the Study:

  • To investigate the state of superficial lymphatic capillaries in severe chronic venous incompetence.
  • To determine the role of lymphatic damage in the formation of indurated edema.

Main Methods:

  • Subepidermal injection of FITC-dextran 150,000 to visualize lymphatic networks.
  • Assessment of lymphatic capillary integrity, permeability, and reflux phenomena.

Main Results:

  • The lymphatic capillary network in the medial ankle region is often interrupted or destroyed.

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  • Evidence of increased lymphatic capillary permeability (dye leakage) and cutaneous reflux was observed.
  • Lymphatic microangiopathy was diagnosed in patients with severe chronic venous incompetence.

    • Conclusions:

    • Lymphatic microangiopathy is a significant finding in severe chronic venous incompetence.
    • Damage to lymphatic capillaries contributes to the development of indurated edema in this condition.