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Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice

Junyan Tao1, Diego F Calvisi2, Sarangarajan Ranganathan3

  • 1Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA.

Gastroenterology
|May 20, 2014
PubMed
Summary

Beta-catenin and Yes-associated protein 1 (Yap1) physically interact and are activated in hepatoblastoma. Their co-activation drives rapid liver tumor development in mice, suggesting new therapeutic targets for this cancer.

Keywords:
Gene RegulationLiver CancerOncogeneTumor Formation

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