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Related Experiment Videos

Uterus retrieval process from brain dead donors.

Tristan Gauthier1, Pascal Piver1, Nicolas Pichon2

  • 1Department of Obstetrics and Gynecology, Limoges University Hospital, Limoges, France.

Fertility and Sterility
|May 20, 2014
PubMed
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Human uterus retrieval after brain death is feasible and accepted by donor families. This organ procurement procedure did not impact other vital organ retrievals, showing promise for future transplantation projects.

Area of Science:

  • Transplantation immunology
  • Organ procurement
  • Reproductive medicine

Background:

  • Uterus transplantation is an emerging field offering fertility options to women with uterine factor infertility.
  • Donation after brain death (DBD) is a potential source of organs for transplantation, but uterus retrieval protocols are not well-established.

Purpose of the Study:

  • To assess the feasibility and safety of human uterus retrieval from deceased donors after brain death.
  • To evaluate the tolerance of the retrieved uterus to cold ischemia.
  • To determine the acceptance rate of uterus donation among families of brain-dead donors.

Main Methods:

  • A prospective, single-center study was conducted at a university hospital.
  • Female brain-dead donors were identified, and their families were approached for consent for uterus donation.
Keywords:
Uterusbrain dead donordonation after brain death (DBD)fertilitysurgerytransplantation

Related Experiment Videos

  • A specific surgical protocol was employed for uterus retrieval, preserving hypogastric vessels, parametria, and vaginal fornix. Uterus viability was assessed via histology and TUNEL reaction after 24 hours of cold ischemia.

    • Main Results:

    • Seven uteri were successfully retrieved from 14 eligible female multiorgan donors within a one-year period.
    • No refusals for uterus donation were recorded, and the retrieval procedure did not impede other vital organ procurements.
    • Histological examination revealed minimal morphologic changes and rare apoptosis in uteri after 24 hours of cold ischemia.

    Conclusions:

    • Human uterus retrieval following brain death is a feasible component of multiorgan procurement.
    • Uterus donation is readily accepted by donor families, suggesting a positive outlook for future transplantation initiatives.
    • This preliminary study provides essential data supporting the development of uterus transplantation programs.