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Do we understand any more about bladder interstitial cells?-ICI-RS 2013
Anthony Kanai1, Christopher Fry, Ann Hanna-Mitchell
1University of Pittsburgh, Pittsburgh, Pennsylvania.
Neurourology and Urodynamics
|May 20, 2014
Summary
Interstitial cells (ICs) in the lower urinary tract play a role in bladder function and pathology. While much is known, their precise physiological roles and mechanisms require further investigation.
Area of Science:
- Urology
- Cell Biology
- Physiology
Background:
- Interstitial cells (ICs) are crucial components of the lower urinary tract.
- Their characterization is often based on comparisons with interstitial cells of Cajal in the gastrointestinal tract.
Purpose of the Study:
- To review discussions on lower urinary tract interstitial cells from the 2013 International Consultation on Incontinence-Research Society (ICI-RS) meeting.
- To explore current understanding of IC subtypes, localization, and communication within the bladder.
Main Methods:
- Discussion focused on IC subtypes, localization, and intercellular communication.
- The role of ICs in bladder pathologies and novel research methodologies were also addressed.
Main Results:
- ICs are believed to drive intrinsic contractions in fetal bladders, diminishing postpartum.
- Post-spinal cord injury, enhanced IC activity may contribute to neurogenic detrusor overactivity and incontinence.
- IC-mediated activity appears initiated by urothelial factors and may involve gap junction coupling.
Conclusions:
- Significant information has been gathered on bladder ICs.
- However, many pathophysiological functions and underlying mechanisms remain unclear.
- Further research is essential to fully elucidate the role of ICs in lower urinary tract function and dysfunction.
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