Related Experiment Video

Updated: Apr 29, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

1.1K

Prostate cancer vaccines in combination with additional treatment modalities

Matthew A Uhlman1, Megan T Bing, David M Lubaroff

  • 1Department of Urology, University of Iowa, 375 Newton Road, Iowa City, IA, 52242, USA.

Immunologic Research
|May 20, 2014
PubMed

Insights

Prostate cancer immunotherapy using vaccines is being explored. These vaccines target specific antigens and are increasingly studied in combination with radiation, chemotherapy, and hormone therapy.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Immunotherapy represents a novel therapeutic strategy for prostate cancer.
  • Vaccines targeting prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) are under investigation.

Purpose of the Study:

  • To review and discuss the combination of prostate cancer vaccine immunotherapies with other treatment modalities.
  • To explore the evolving landscape of prostate cancer treatment through immunotherapy combinations.

Main Methods:

  • Review of preclinical studies and clinical trials involving prostate cancer immunotherapy.
  • Analysis of vaccine-based immunotherapies, including dendritic cell, viral, and DNA vaccines.
  • Examination of combination therapies involving radiation, chemotherapy, and androgen deprivation therapy.

Main Results:

  • Vaccine immunotherapies have been studied as monotherapy and in combination regimens.
  • Increasing clinical trials focus on combining vaccine immunotherapies with established treatments.
  • Combinations with radiation, chemotherapy, and androgen deprivation therapy are actively being investigated.

Conclusions:

  • Prostate cancer vaccine immunotherapy is a promising area of research.
  • Combination strategies are expanding the therapeutic potential of prostate cancer vaccines.
  • Further research into these combinations may lead to improved treatment outcomes.

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.4K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.6K

Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.3K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K