Novel devices for solvent delivery and temperature programming designed for capillary liquid chromatography
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Updated: Apr 29, 2026

Simple In-House Ultra-High Performance Capillary Column Manufacturing with the FlashPack Approach
Published on: December 4, 2021
Lincoln Figueira Marins Coutinho1, Carlos Eduardo Domingues Nazario, Alessandra Maffei Monteiro
1Institute of Chemistry of Sao Carlos, University of Sao Paulo, Sao Carlos (SP), Brazil.
Abstract:
Analyses in chromatographic systems able to save mobile and stationary phases without reducing efficiency and resolution are of current interest. These advantages regarding savings have challenged us to develop a system dedicated to miniaturized liquid chromatography. This paper reports on the development of a high-pressure syringe-type pump, an oven able to perform isothermal and temperature programming and a software program to control these chromatographic devices. The experimental results show that the miniaturized system can generate reproducible and accurate temperature and flow rate. The system was applied to the separation of statins and tetracylines and showed excellent performance.
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