Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blinding01:11

Blinding

2.9K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.9K
Randomized Experiments01:13

Randomized Experiments

6.3K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
6.3K
Ethics in Research01:56

Ethics in Research

23.7K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
23.7K
Nurses' Legal Responsibilities I01:27

Nurses' Legal Responsibilities I

2.4K
In healthcare, informed consent is a crucial process that involves thoroughly communicating medical treatment options to patients, including benefits, risks, potential side effects, and alternatives. This process enables patients to make well-informed decisions about their care, ensuring they understand the implications of their choices before consenting to or refusing treatment.
The legal responsibilities of a nurse regarding informed consent include the following:
2.4K
Clinical Trials01:16

Clinical Trials

8.5K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
8.5K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

627
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
627

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Readiness and recovery: Transferring between methadone and buprenorphine/naloxone for the treatment of opioid use disorder.

International journal of mental health nursing·2018
Same author

The effect of additional mealtime insulin bolus using an insulin-to-protein ratio compared to usual carbohydrate counting on postprandial glucose in those with type 1 diabetes who usually follow a carbohydrate-restricted diet: A randomized cross-over trial.

Diabetes, obesity & metabolism·2018
Same author

Access to diabetes drugs in New Zealand is inadequate.

The New Zealand medical journal·2016
Same author

A randomised trial of the feasibility of a low carbohydrate diet vs standard carbohydrate counting in adults with type 1 diabetes taking body weight into account.

Asia Pacific journal of clinical nutrition·2016
Same author

From 'pleasure to chemistry': the experience of carbohydrate counting with and without carbohydrate restriction for people with Type 1 diabetes.

Journal of primary health care·2015
Same author

Primary health-care nurses and Internet health information-seeking: Access, barriers and quality checks.

International journal of nursing practice·2014

Related Experiment Video

Updated: Apr 29, 2026

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

9.7K

The informed consent process in randomised controlled trials: a nurse-led process.

Pip Cresswell, Jean Gilmour

    Nursing Praxis in New Zealand Inc
    |May 21, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Clinical research nurses play a vital role in the informed consent process for clinical trials. Their involvement ensures participant understanding and safety, highlighting a nurse-led approach to research ethics.

    More Related Videos

    A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
    04:53

    A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

    Published on: September 20, 2019

    10.1K
    E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
    06:28

    E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

    Published on: August 1, 2019

    8.0K

    Related Experiment Videos

    Last Updated: Apr 29, 2026

    Working with Human Tissues for Translational Cancer Research
    07:48

    Working with Human Tissues for Translational Cancer Research

    Published on: November 26, 2015

    9.7K
    A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
    04:53

    A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

    Published on: September 20, 2019

    10.1K
    E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
    06:28

    E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

    Published on: August 1, 2019

    8.0K

    Area of Science:

    • Clinical Research
    • Nursing Practice
    • Bioethics

    Background:

    • Informed consent is crucial for ethical clinical trials involving human participants.
    • Randomized controlled trials (RCTs) offer strong evidence but present comprehension challenges for clinicians and patients.
    • The clinical research nurse role in ensuring informed consent in RCTs is increasingly recognized.

    Purpose of the Study:

    • To explore in-depth the clinical research nurse's role in the informed consent process.
    • To understand the complexities and skills involved in obtaining informed consent for RCTs.
    • To identify how nursing practice contributes to ethical and effective clinical trial conduct.

    Main Methods:

    • Qualitative descriptive study design.
    • Semi-structured interviews with three clinical research nurses.
    • Thematic analysis of interview data to identify key themes.

    Main Results:

    • Three core themes emerged: Preparatory partnerships, Partnering the participant, and Partnership with the project.
    • Ensuring informed consent in RCTs is a complex, multi-faceted process requiring diverse nursing skills.
    • The study highlights the critical contribution of clinical research nurses in protecting participants and promoting research quality.

    Conclusions:

    • The informed consent process in clinical trials can be effectively led by nurses.
    • Acknowledging and recognizing the clinical research nurse's role in informed consent is essential for professional development and industry recognition.
    • This study enhances understanding of nursing's contribution to ethical research conduct and participant safety.