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Published on: August 31, 2016
Evaluation of Cardiac Markers in Children Undergoing Hematopoietic Stem Cell Transplantation
Gulfer Ozturk1, Betul Tavil2, Meltem Ozguner3
1Department of Biochemistry Diskapi Yildirim Beyazit Education and Research Hospital.
Insights
Hematopoietic stem cell transplantation (HSCT) can cause cardiotoxicity. Heart-type fatty acid binding protein (H-FABP) and high-sensitivity C-reactive protein (hsCRP) show promise in monitoring cardiac health during HSCT.
Area of Science:
- Cardiology
- Hematology
- Oncology
Background:
- Hematopoietic stem cell transplantation (HSCT) is associated with life-threatening cardiotoxicity and cardiac death.
- Early detection of cardiac damage is crucial for managing HSCT patients.
Purpose of the Study:
- To evaluate cardiotoxicity following conventional chemotherapy and HSCT.
- To assess the efficacy of specific cardiac biomarkers in detecting HSCT-related cardiac events.
Main Methods:
- A cohort of 20 pediatric patients undergoing HSCT for various diseases was studied.
- Cardiac biomarkers including H-FABP, GPBB, hsCRP, cTnI, CK-MB mass, and myoglobin were measured on days 0, 7, and 21 post-HSCT.
- Echocardiography was performed before and one month after HSCT.
Main Results:
- Serum H-FABP levels were significantly elevated by day 21 post-HSCT (P < 0.05).
- hsCRP levels peaked on day 7 and were significantly higher than on days 0 and 21 (P < 0.05).
- GPBB levels decreased significantly by day 7 (P < 0.05), while myoglobin, cTnI, and CK-MB mass remained within normal ranges.
Conclusions:
- H-FABP and hsCRP emerge as sensitive indicators for monitoring cardiotoxicity during HSCT.
- These markers may offer superior detection capabilities compared to GPBB, cTnI, CK-MB mass, and myoglobin in this context.
Background:
Early life-threatening cardiotoxicity and cardiac death have been reported after hematopoietic stem cell transplantation (HSCT). The purpose of the current study was to evaluate cardiac toxicity of conventional chemotherapy followed by HSCT with cardiac markers: heart-type fatty acid binding protein (H-FABP), glycogen phosphorylase BB (GPBB), high sensitive C reactive protein (hsCRP) cardiac troponin I, (cTnI), creatine kinase MB (CK-MB mass) and myoglobin.
Methods:
A total of 20 children who underwent HSCT for malignant and non-malignant diseases were included in this study. Blood samples were collected from all patients in 0th, 7th and 21st day for evaluating these cardiac biomarkers. The patients' echocardiography was assessment before and after one-month of HSCT.
Results:
Serum 21st H-FABP level was significantly higher when compared with the 0th day H-FABP level (P < 0.05) . 7th day hsCRP level was significantly higher than 0th and 21st day levels (P < 0.05). Interestingly, 7th day GPBB level was significantly lower than 0th and 21st day levels (P < 0.05). Myoglobin, CK-MB mass and cTnI biomarkers remained within the reference range in all patients.
Conclusions:
This study showed that H-FABP and hsCRP both seem to be promising markers for evaluation of cardiotoxicity in HSCT process and probably superior to GPBB, cTnI, CK-MB mass and myoglobin.
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