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Targeting PINK1 and MQC in brain tumors

Kyu-Sun Lee1, Bingwei Lu

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, CA94304, USA.

Oncotarget
|May 21, 2014
PubMed
Abstract

No abstract available in PubMed .

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
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