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Updated: Apr 29, 2026
Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems
Published on: July 4, 2011
"Turn-on" fluorescent dipodal chemosensor for nano-molar detection of Zn(2+): application in living cells imaging
Umesh Fegade1, Hemant Sharma2, Banashree Bondhopadhyay3
1School of Chemical Sciences, North Maharashtra University, Jalgaon 425001, Maharashtra, India; School of Environmental and Earth Sciences, North Maharashtra University, Jalgaon 425001, Maharashtra, India.
Abstract:
A malonohydrazide derivative bearing an imine and phenolic group was synthesized and had a high affinity and selectivity towards Zn(2+). The recognition properties of receptor 1 were evaluated using absorbance and fluorescence spectroscopy. The 1:1 stoichiometry of 1.Zn(2+) was confirmed from job's plot, mass spectra and density functional theory (DFT). The detection of Zn(2+) in intracellular environment of HeLa cell through confocal microscopy was successfully applied for live cell imaging.
