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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Transient increase in circulating myeloid-derived suppressor cells after partial bladder outlet obstruction.
Wei-Yu Lin1, Ching Chuan Hsieh1, Teng-Yao Yang1
1Division of Urology, Department of Surgery (WYL, LYH, YPL), Chang Gung Memorial Hospital, Chia-Yi, Taiwan, Republic of China; Department of Surgery (CCH), Chang Gung Memorial Hospital, Chia-Yi, Taiwan, Republic of China; Department of Cardiology (TYY), Chang Gung Memorial Hospital, Chia-Yi, Taiwan, Republic of China; Chang Gung University of Science and Technology (WYL), Chia-Yi, Taiwan, Republic of China; Department of Medicine and Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University (WYL), Taoyuan, Taiwan, Republic of China; Department of Nutrition and Health Sciences, College of Health Science, Innovate Research Center of Medicine, Chang Jung Christian University (MLC), Tainan, Taiwan, Republic of China; Department of Medicine, Mackay Medical College (YHW), New Taipei City, Taiwan, Republic of China; Albany College of Pharmacy and Health Sciences and Stratton Veterans Affairs Medical Center, Albany (RML), New York.
Partial bladder outlet obstruction increases myeloid-derived suppressor cells, IFN-γ, IL-10, and aldosterone. Reversing the obstruction normalized these markers, suggesting their potential as indicators for urinary symptom risk.
Area of Science:
- Urology
- Immunology
- Physiology
Background:
- Partial bladder outlet obstruction (PBО) is linked to increased oxidative stress and inflammation.
- Myeloid-derived suppressor cells (MDSCs), IFN-γ, IL-10, and aldosterone are implicated in PBО-associated oxidative stress and inflammation.
Purpose of the Study:
- To investigate changes in plasma MDSCs, IFN-γ, IL-10, and aldosterone in rats with PBО.
- To assess the impact of PBО reversal on these plasma markers.
Main Methods:
- Surgically induced PBО in rats.
- Groups included sham-treated, 4-week obstruction, and 4/8-week obstruction with relief.
- Plasma levels of MDSCs, IFN-γ, IL-10, and aldosterone were measured using flow cytometry and ELISA.
Main Results:
- PBО significantly increased circulating MDSCs, IFN-γ, IL-10, and aldosterone compared to sham controls.
- Obstruction reversal at 4 and 8 weeks normalized these elevated plasma levels.
Conclusions:
- Elevated plasma MDSCs, IFN-γ, IL-10, and aldosterone in PBО rats normalize upon obstruction relief.
- These markers may serve as predictive indicators for patients at higher risk of urinary symptoms.
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