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A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

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Published on: November 8, 2019

Microcirculation changes during liver resection--a clinical study.

Jan Nilsson¹, Sam Eriksson¹, Per-Jonas Blind¹

¹Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden.

Microvascular Research

|May 21, 2014

Summary

This summary is machine-generated.

Liver resection increases red blood cell velocity (RBCV) in the liver. Sidestream dark-field (SDF) imaging may help detect liver damage during surgery.

Keywords:

Chemotherapy Hepatic microcirculation Liver function Sidestream dark-field imaging Steatosis

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A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

Published on: October 6, 2018

Area of Science:

Hepatobiliary surgery
Surgical physiology
Medical imaging

Background:

Liver resection impacts hepatic microcirculation.
Intraoperative detection of liver damage is crucial.

Purpose of the Study:

Evaluate the effects of liver resection on hepatic microcirculation.
Assess the utility of sidestream dark-field (SDF) imaging for intraoperative detection of histological liver damage.

Main Methods:

40 patients undergoing hepatic resection were studied.
Hepatic microcirculation was assessed using SDF imaging before and after resection.
Measurements included red blood cell velocity (RBCV), sinusoidal diameter, and functional sinusoidal density.

Main Results:

Hepatic resection led to increased RBCV in both minor and major resection groups.
RBCV was significantly higher in patients with histological liver damage compared to those without (225 vs. 161 μm/s).

Conclusions:

Liver resection increases sinusoidal RBCV.
SDF imaging shows potential for intraoperative identification of histological liver damage.