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Updated: Apr 29, 2026
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Published on: November 8, 2019
Microcirculation changes during liver resection--a clinical study
Jan Nilsson1, Sam Eriksson1, Per-Jonas Blind1
1Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden.
Background:
In this study we aimed to evaluate effects of liver resection on hepatic microcirculation. In addition we wanted to study if histological liver damage could be detected intra-operatively.
Patients And Methods:
40 patients undergoing hepatic resection were included and grouped according to if they were operated with a major or minor resection. Hepatic microcirculation measurements were made intra-operatively before and after liver resection with sidestream dark-field (SDF) imaging. Red blood cell velocity (RBCV), sinusoidal diameter and functional sinusoidal density were determined.
Results:
After hepatic resection RBCV increased in both the minor and major groups (44 μm/s, P=0.016 and 121 μm/s, P=0.002). RBCV in patients with histological damages was 225 (148-464) μm/s vs. 161 (118-329) μm/s in patients with no damage (P=0.016).
Conclusion:
A hepatic resection leads to an increase of sinusoidal RBCV. SDF imaging could potentially be used to intraoperatively identify histological damages.
