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Updated: Apr 29, 2026
A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
Published on: August 7, 2020
Hepatocellular carcinoma: genome-scale metabolic models for hepatocellular carcinoma
Roser Pinyol1, Josep M Llovet1
1HCC Translational Research Laboratory, Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit, Hospital Clínic Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Rosselló 153, 08036 Barcelona, Spain.
Abstract:
A new study proposes a modelling strategy to identify reactions, genes and metabolites relevant in hepatocellular carcinoma using in silico and in vivo analyses. The proposed genome-scale metabolic model integrates genomic and proteomic information, and points to statins, among others, as potential chemopreventive and anticancer drugs.
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