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Updated: Apr 29, 2026

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
Published on: August 16, 2018
New triterpenoids with protein tyrosine phosphatase 1B inhibition from Cedrela odorata
Wen-Bin Wu1, Hua Zhang, Shi-Hui Dong
1a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
Abstract:
Two new apotirucallane-type triterpenoids, cedrodorols A-B (1 and 2), along with seven known compounds (3-9), were isolated from the twigs and leaves of Cedrela odorata. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with the IC50 values of 13.09 and 3.93 μg/ml, respectively.
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