Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet aggregation, secretion, and coagulation changes in children with asthma.

Gonul Buyukyilmaz1, Ozge U Soyer, Betul Buyuktiryaki

  • 1aDepartment of Pediatrics, Ankara Education and Research Hospital, The Ministry of Health of Turkey bDepartment of Pediatric Allergy, Hacettepe University, School of Medicine cDepartment of Pediatric Hematology, The Ministry of Health of Turkey, Ankara Education and Research Hospital, Ankara, Turkey *Gonul Buyukyilmaz and Ozge U. Soyer contributed equally to this article.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|May 21, 2014
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One-hour glucose-defined metabolic phenotypes in youth with obesity: early β-cell impairment across the spectrum of dysglycemia.

Diabetes research and clinical practice·2026
Same author

Impact of growth hormone preparation switching on treatment outcomes in children with growth hormone deficiency: a retrospective real-world cohort study.

BMC endocrine disorders·2026
Same author

The Effect of an Augmented Reality Game on Pain and Fear Levels and Care Satisfaction During Allergy Testing in Children Aged 4-12: A Randomized Controlled Study.

Pain management nursing : official journal of the American Society of Pain Management Nurses·2026
Same author

Clinical characteristics and endocrine outcomes of functional and nonfunctional adrenal lesions in children: a single-center cohort study.

Journal of pediatric endocrinology & metabolism : JPEM·2026
Same author

CHOPS Syndrome: A Rare Malformation Syndrome with de novo AFF4 Gene Variant.

Molecular syndromology·2026
Same author

Genotype-Phenotype Spectrum of Non-Syndromic Monogenic Obesity in a National Paediatric Cohort.

Pediatric obesity·2026

Platelets play a role in asthma. Children with asthma attacks showed reduced platelet secretion and higher levels of von Willebrand factor (vWF) and factor VIII (FVIII), suggesting coagulation mechanisms are key in asthma.

Area of Science:

  • Pediatric Allergy and Immunology
  • Hematology
  • Respiratory Medicine

Background:

  • Asthma involves chronic inflammation mediated by various immune cells.
  • Platelets, primarily known for hemostasis, are increasingly recognized for their role in asthma pathogenesis, particularly during antigen provocation and exacerbations.

Purpose of the Study:

  • To investigate platelet function and hemostatic markers in children with asthma.
  • To compare these parameters during symptom-free periods versus asthma attacks.

Main Methods:

  • Evaluated platelet aggregation and secretion (ATP release) using a lumiaggregometer with various agonists (collagen, epinephrine, ADP, thrombin, ristocetin, arachidonic acid).
  • Assessed plasma levels of D-dimer, factor VIII (FVIII), and von Willebrand factor (vWF).

Related Experiment Videos

  • Included children with asthma attacks, mild intermittent asthma, mild persistent asthma, and healthy controls.

    • Main Results:

    • No significant differences in agonist-induced platelet aggregation were observed between groups.
    • Platelet ATP release stimulated by ADP and epinephrine was significantly lower in children experiencing asthma attacks compared to other groups and controls.
    • Plasma vWF levels were elevated in children with asthma attacks, and FVIII levels increased in those with severe attacks.

    Conclusions:

    • Platelet secretion profiles differ in children with asthma attacks.
    • Elevated vWF and FVIII levels in asthma exacerbations suggest a role for coagulation pathways.
    • These findings highlight the potential critical involvement of coagulation mechanisms in asthma pathogenesis.