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Lack of association between matrix metalloproteinase-9 gene-1562C/T polymorphism and preeclampsia: a meta-analysis
Li-Li Gong1, He Liu, Li-Hong Liu
1Beijing Chao-Yang Hospital affiliated with Beijing Capital Medical University , Beijing , China.
Abstract:
Studies investigating the association between matrix metalloproteinases (MMPs) gene polymorphisms and preeclampsia (PE) reported contradictory or non-conclusive results. We performed a meta-analysis of five studies that examined the relationship between PE and the MMP9-1562C>T polymorphism. The PubMed, Embase, and Google Scholar databases were searched to access the relevant genetic association studies up to September 2013. The meta-analysis revealed that there was no evidence for significant association between MMP9-1562C>T polymorphism and risk of PE. Large, multiethnic confirmatory, and well-designed studies are needed to further explore the relation between preeclampsia and polymorphisms of the MMPs gene.
Insights
This meta-analysis found no significant link between the MMP9-1562C>T gene polymorphism and preeclampsia (PE) risk. Further large-scale studies are needed to clarify the relationship between matrix metalloproteinases gene variations and PE.
Area of Science:
- Genetics
- Obstetrics
- Molecular Biology
Background:
- Preeclampsia (PE) is a major complication of pregnancy.
- Matrix metalloproteinases (MMPs) are implicated in placental development and function.
- Previous studies on MMPs gene polymorphisms and PE risk have yielded inconsistent results.
Purpose of the Study:
- To conduct a meta-analysis investigating the association between the MMP9-1562C>T polymorphism and preeclampsia risk.
Main Methods:
- A systematic literature search was performed on PubMed, Embase, and Google Scholar up to September 2013.
- Five genetic association studies examining the MMP9-1562C>T polymorphism and PE were included.
- Meta-analysis techniques were employed to synthesize the data.
Main Results:
- The meta-analysis found no statistically significant association between the MMP9-1562C>T polymorphism and the risk of developing preeclampsia.
- The pooled data did not support a role for this specific MMP9 variant in PE susceptibility.
Conclusions:
- The MMP9-1562C>T polymorphism is not significantly associated with preeclampsia risk.
- Larger, multiethnic, and well-designed studies are required to definitively explore the relationship between MMPs gene polymorphisms and preeclampsia.