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Proliferative glomerulonephritis with monoclonal immunoglobulin A light-chain deposits in the renal allograft
Kiyoshi Setoguchi1, Yoichiro Kawashima, Tadahiko Tokumoto
1Department of Transplant Surgery and Urology, Toda-chuo General Hospital, Saitama, Japan; Department of Urology, Saiseikai Kurihashi Hospital, Saitama, Japan.
Abstract:
We herein describe the unique case of a 59-year-old man who underwent living kidney transplantation for IgA nephropathy (IgAN) and developed progressive kidney failure associated with the appearance of proliferative glomerulonephritis. An early protocol biopsy revealed recurrent IgAN with mesangial IgA2 deposits restricted to a single immunoglobulin λ light-chain isotype. Despite treatment with tonsillectomy and rituximab, the patient eventually lost his allograft 31 months after transplantation. Serum electrophoresis showed a monoclonal IgA pattern. This case might share common pathological characteristics with the newly described entity referred to as proliferative glomerulonephritis with monoclonal IgG deposits.