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Normal CD4 Count Range among Healthy Nigerian Population in Ilorin
J K Afolabi1, A Fadeyi2, O O Desalu3
11 Peadiatric Department, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
Summary
This study establishes a new CD4 count range for healthy Nigerians in Ilorin, finding it lower than national values. This CD4 count data is crucial for monitoring immune status.
Area of Science:
- Immunology
- Hematology
- Public Health
Background:
- CD4 count is essential for assessing immune status.
- Accurate CD4 count ranges are vital for disease monitoring.
- Establishing local reference values improves diagnostic accuracy.
Purpose of the Study:
- Determine the CD4 count range in apparently healthy Nigerians residing in Ilorin.
- Compare these findings with established national CD4 count reference values.
- Investigate demographic influences on CD4 counts within the study population.
Main Methods:
- Utilized an automated blood analyzer for complete blood count and CD4 enumeration.
- Calculated CD4 percentage using derived variables.
- Analyzed data from 1205 participants to establish reference ranges.
Main Results:
- Established adult CD4 count range: 400-1288 cells/mm³ (19%-48%); children: 582-3652 cells/mm³ (17%-50%).
- Females exhibited significantly higher CD4 counts and percentages than males (P=.001).
- Absolute CD4 count in Ilorin adults (808 ± 260) was significantly lower than the national average (847.0 ± 307.0, P=.001).
Conclusions:
- Advocates for the adoption of the study-derived CD4 count range for Ilorin residents.
- Highlights the need for geographically specific CD4 count reference values.
- Suggests potential regional variations in immune status indicators.
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