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Primary Culture of Adult Rat Heart Myocytes
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Primary Culture of Adult Rat Heart Myocytes

Published on: June 16, 2009

Postnatal changes in muscarinic receptor subtype mRNAs in rat brain and heart

R Pinkas-Kramarski1, R Stein, M Sokolovsky

  • 1Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.

Journal of Molecular Neuroscience : MN
|January 1, 1989
PubMed

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Cholinergic Receptors: Muscarinic01:25

Cholinergic Receptors: Muscarinic

The pharmacological actions of acetylcholine are elicited via its binding to two families of cholinergic receptors or cholinoceptors, namely, muscarinic and nicotinic receptors. Muscarinic receptors are G protein-coupled receptors and have five subtypes, M1–M5. All mAChR subtypes are activated by acetylcholine and blocked by the antagonist, atropine. 
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+. Activation...