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Epistatic Interactions between CREB and CREM Variants in Affective Disorder
Alberto Chiesa1, Agnese Marsano2, Changsu Han3
1Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy. ; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Psychiatry Investigation
|May 21, 2014
Summary
This study found no evidence of epistatic interactions between CREB and CREM gene variants influencing psychotropic drug response in bipolar disorder and major depressive disorder patients. These genetic factors do not appear to affect clinical improvement or treatment outcomes.
Area of Science:
- Pharmacogenetics
- Neuroscience
- Genetics
Background:
- Bipolar disorder (BD) and major depressive disorder (MDD) are complex psychiatric conditions.
- Genetic factors play a role in psychotropic medication response.
- Epistasis, gene-gene interactions, may influence treatment outcomes.
Purpose of the Study:
- To investigate potential epistatic interactions between Cyclic adenosine monophosphate Response Element Binding (CREB) rs6740584 and cAMP response element-modulator (CREM) rs12775799 variants.
- To determine if these interactions affect psychotropic agent response in BD and MDD patients.
- To explore associations with clinical factors and symptom improvement.
Main Methods:
- A cohort of BD and MDD patients was assessed.
- The Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HAMD) were used for symptom evaluation.
- Multiple regression models analyzed epistatic interactions between CREB and CREM variants and clinical outcomes.
Main Results:
- No significant epistatic interaction was detected between the CREB (rs6740584) and CREM (rs12775799) variants.
- These genetic variants did not show a significant influence on symptom improvement in affective disorders.
- No association was found with other clinical factors.
Conclusions:
- The investigated CREB and CREM variants do not appear to interact epistasically to influence psychotropic drug response in BD and MDD.
- Preliminary findings suggest a lack of epistatic effect on clinical improvement and factors in affective disorders.