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Highly Protective Association of MMP-2-1306C/T Promoter Polymorphism With Asthma in a North Indian Population: A

Niti Birbian1, Jagtar Singh1, Surinder Kumar Jindal2

  • 1Department of Biotechnology, Panjab University, Chandigarh, India.

Allergy, Asthma & Immunology Research
|May 21, 2014
PubMed
Abstract

Insights

This study found that the MMP-2 -1306C/T promoter polymorphism offers significant protection against asthma in North India. The T allele and its genotypes (CT, TT) were associated with a reduced risk of developing asthma.

Area of Science:

  • Genetics and Molecular Biology
  • Respiratory Medicine
  • Human Population Studies

Background:

  • Asthma is a major public health concern in India, identified as the most prevalent disease in national surveys.
  • Matrix metalloproteinase-2 (MMP-2), an enzyme involved in collagen degradation and inflammation, is implicated in various pathological processes.
  • The role of specific genetic variations, such as single nucleotide polymorphisms (SNPs) in the MMP-2 gene promoter, in asthma pathogenesis requires further investigation.

Purpose of the Study:

  • To evaluate the association between the MMP-2 -1306C/T promoter single nucleotide polymorphism (SNP) and asthma in a North Indian population.
  • To investigate the potential protective role of the MMP-2 -1306C/T polymorphism in the development of asthma.
  • To examine the relationship between this polymorphism and various asthma phenotypic traits.

Main Methods:

  • A case-control study was conducted with 410 adult asthma patients and 414 healthy adult controls from North India.
  • Genotyping of the MMP-2 -1306C/T polymorphism was performed using Tetra-Primer Amplification Refractory Mutation System Polymerase Chain Reaction (Tetra-Primer ARMS PCR).
  • Statistical analyses, including odds ratios (OR) and confidence intervals (CI), were used to assess the association between the polymorphism and asthma.

Main Results:

  • The T allele of the MMP-2 -1306C/T polymorphism demonstrated a highly protective effect against asthma (OR=0.45, P=0.000).
  • Both heterozygous (CT) and homozygous (TT) genotypes of this polymorphism were significantly associated with protection from asthma (CT: OR=0.37, P=0.000; TT: OR=0.35, P=0.002).
  • The MMP-2 -1306C/T polymorphism showed a significant association with all evaluated phenotypic traits of asthma.

Conclusions:

  • The MMP-2 -1306C/T promoter polymorphism provides significant protection against asthma in the North Indian population studied.
  • This finding suggests a potential genetic marker for asthma risk or protection within this demographic.
  • Further research may explore the functional mechanisms underlying the protective role of this MMP-2 polymorphism in asthma.
Keywords:
Asthmacollagenasematrix metalloproteinase-2 (MMP-2)polymorphism

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